The Pitfall of Alcohol

I’ve been avoiding writing this post for at least a week, probably two. Mostly because it has personal meaning to me as alcoholism runs in my family on both sides – My mothers father was one of the “Mad Men” of the 50’s, worked in advertising and died of liver failure due to alcoholism. I guess he got pretty ugly in the end. My paternal grandparents didnt drink at all (which leads me to wonder if their parents were alcoholic) but all of their children have a penchant for the sauce.

Before I was a medical student, I thought the damaging effects of alcohol could be traced directly by measuring liver enzymes – and as long as those harbingers of hepatic cell death stayed within a reasonable limit, one was “getting away” with whatever one was doing. Enter: neurology. Boy was I wrong. Oh and Ps. Dead liver cells cant release ALT or AST, so good liver enzymes in the face of chronic alcoholism is actually a pretty bad sign.

The blood brain barrier is an effective barrier to most things except: nonpolar and lipid soluble molecules. Enter: CO2, O2, and ETOH (alcohol.) This means that as soon as alcohol is in your blood, it is seeping into your brain. And brain cells/ neurons are permanent cells – they don’t have the ability to divide, so they don’t replicate. You get what you started with – some axons can be regenerated, but once the cell body dies, your numbers start to decrease.

gait-ataxiaThe cerebellum is one of the parts of the brain most affected by alcohol cell death; this is why people become unsteady and clumsy anterior-vermiswhen drunk – inhibition of cerebellar function! There are multiple and complex inputs to this lower brain region from almost every aspect of the nervous system, so it can compensate for loss of neurons (when sober) for a long time. Up to 80% of cell death can happen before symptoms become noticeable! Unfortunately, once this is happening in the sober state, the cells are dead and there is no ability to recover balance or coordination.

I didn’t know that memory loss is also a component of chronic alcoholism. There are two halves to the cognitive decline that will happen eventually called Wernicke-Korsakoff syndrome, and these are from alcohol related destruction to two more areas of the brain.

confusionThe first set of symptoms is reversible, and is related to a deficiency of vitamin B1 aka thiamine. The mammillary bodies are wee nubs on the underside of the brain that are part of the social and emotional brain. They take information from the hypothalamus and hippocampus, and run it to the anterior nucleus of the thalamus. nrhpth08

 

 

 

 

This is a critical loop in emotional and social behavior integration at a cognitive level. I guess this is partially where the numbing effect of alcohol on the emotions could occur? With a deficiency of B1, the mammillary bodies hemorrhage and cause Wernickes encephalopathy, characterized by confusion and your eyes not tracking properly, as well as the unsteadiness from the damaged cerebellum. This is why in hospital treatments, alcoholics are first given thiamine/ B1 to see if it can reverse the symptoms. From a prevention standpoint, taking a good quality capsule (not tablet) daily multivitamin seems like a good idea for anyone drinking on a regular basis.

This condition can progress to irreversible memory loss for the past, with an inability to make new memories, plus psychotic symptoms. This is called Korsakoff psychosis. As people lose their ability to remember, they start making things up to fill in the blanks called confabulation. This can be really depressing for friends and family members as it becomes clearly evident that the damage is permanent.

and THEN, there is the metabolic damage that is occurring below the neck. (This next section is biochemical mumbo jumbo, but since this is my review exercise, I’m going to include it for my medical interest:)

screen-shot-2016-09-26-at-12-32-00-pmEthanol/ your drinks/ are 80% broken down by cells (cytosol) of the liver. 15% of alcohol is broken down by microsomes in the brain and liver, and this pathway is upregulated in chronic alcoholism. The remaining 5% are converted to fatty acids and phospholipids that are thought to play a role in tissue damage. Both primary pathways break down ethanol to acetaldehyde, which is metabolized  down to acetate…..Acetate, where have you heard that before? yes, NAIL POLISH REMOVER, flooding your liver and brain.

The major metabolic consequence is from the elevation of NADH that occurs in the cell and in the mitochondria in steps one and two with excessive and continual amounts of alcohol intake, because this NADH will inhibit the TCA cycle from running. No TCA = no glucose metabolism = no fuel for the cells. The brain will still need fuel, so the liver cleverly shifts the glucose from the alcohol (which can no longer be metabolized) to ketone production + free fatty acid synthesis (aka fat storage.) This explains, in painful detail, why alcohol makes you gain weight and affects blood sugar levels.

screen-shot-2016-09-26-at-12-36-56-pmFinally, I wanted to add this last slide for an important prevention note. This is the process of the 15% microsomal pathway that is upregulated with chronic high alcohol intake. Note the second step produces ROS – this is reactive oxygen species aka free radicals which are known to cause cell damage and cell death. Higher levels of ROS are bad in general and associated with greater inflammation and cellular damage across the board. This points to another potential place for prevention – with use of high dose antioxidants like CoQ10 200-300mg, resveratrol (500mg), alpha lipoic acid (200mg) and vitamins C (1000mg) and mixed tocopherol E (400IU).

screen-shot-2016-10-08-at-4-29-14-pmWhen alcohol intake gets high enough to start causing brain damage, obviously the primary treatment goal is to reduce the intake. Our first case study had a 37 yo male drinking 12-16 beers PER DAY. How many drinks, realistically speaking, are you having per day? How many does that add up to per week? Does that seem reasonable to you?

I don’t know enough about addiction to know how to address real chronic alcoholism. I imagine it is incredibly hard to quit, and even to reduce daily intake without a pure and strong internal directive to do so – no one can be told to do it,  the drive Must Come from Within. Treating underlying depression, anxiety, or life stressors are surely part of the picture, but what if you just drink to have fun? Sometimes, the party needs to stop, or gets out of control. I guess we all need to grow up sometime and learn to tolerate whatever it is we harbor inside our minds (before they get destroyed.)

Alcohol is a depressant, so withdrawal symptoms are the opposite – agitation, irritation, worse case scenario people can have seizures. Benzodiazapines, some sleep drugs and alcohol all work on the GABA-A receptor in the brain. Chronic alcohol use downregulates the expression the neurotransmitter GABA, one of the “off switches.” Once high levels of alcohol start to lower, it takes time for the brain to start making enough GABA again, resulting in foul moods, irritability and general unpleasantness.

There are medications like naltrexone and acamprosate that can help reduce the cravings for alcohol, and medications to treat the side effects of withdrawal, mostly aimed at these same parts of the brain. These are definitely worth exploring with a psychiatrist or addiction specialist to figure out what approach will work best for you. Complete abstinence does not need to be the goal. GABA as a supplement is not absorbed well, but is readily available and might be worth a try for someone who is just cutting down on daily intake, and has addictive enough a personality that switching to benzos instead of alcohol could exacerbate rather than relieve the problems. However, it is unlikely GABA alone would be enough to support sobriety. Making the very personal and often terrifying choice to look at one’s habits and face trauma/addiction is the place to begin. A comprehensive medical assessment with an empathetic and respectful health professional who has experience in addiction is next step. (if you are in Maine, I highly recommend Dr. Merideth Norris!)

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Will Power

I am two weeks into second year medical school, and the majority of our content has been NeuroAnatomy and Brain Diseases. As a physician it is pretty darn important to be able to figure out when someone is having a life threatening stroke impinging on brain tissue,  versus a flare up of a genetic disorder that is starting to show neurological signs and symptoms. Knowing the anatomy of the brainstem, and the arrangement and progression of the long tracts of nerve fibers throughout the spinal cord, medulla, pons, brainstem and beyond can create a Cartesian like diagram where one can fairly accurately isolate the nature and location of the lesion. That is, if you can remember where and how everything goes.

Brainstem_07-02_smallI never quite knew where the medulla was even located, and now I know more than I probably ever will again about the arrangement of nerves, radiations and nuclear cell bodies in its little bulbous body. This tiny part of the body has nerve fibers that do cardiorespiratory regulation, the trigeminal cranial nerve nucleus, tracts, and radiations for face sensation, ascending dorsal column and spinothalamic sensory tracts for the entire body, descending corticospinal and pyramidal motor tracts for the entire body, and some complicated cranial nerve regulating nucleii that coordinate the eyes and hearing. As you go up fun things show up like the olives, and the solitary nucleus and nucleus ambiguous (both associated with the vagus nerve.) And, the tongue. Problems with the tongue can be from a medullary lesion including slurred speech and not being able to stick your tongue out at someone very effectively, because it points wiggly off to the side the damage has occurred. There is probably more things in this tiny medulla oblongata, but I cant remember them right now.

Starting back into school is also an exercise in letting go. I am fairly certain this is a cerebral condition, and not a brainstem function.  Letting go of free time, of relaxation, of life without an alarm clock. It takes a lot of will power to focus for so many hours at a time. I personally also find myself needing to cut back on alcohol, Netflicks and social time with the advent of academics.  I have been having a lot of conversations about this topic of will power lately, as in, do I have enough, or am I lacking? I have such restricted foods from all of my food sensitivities that I feel like I have pretty good will power overall but maybe, just maybe I could work on a higher level control of some of my more primitive impulses (stay tuned for amydala updates next week.)

untitledBack to the topic of stroke. And willpower. Smoking is a huge risk for stroke, especially intraparenchymal stroke. 45% of people die within the first 30 days of having a stroke. Why? Because the brain is special. And when you put pressure on it, by adding more fluid (blood) into a closed small area (the skull, or calverium as I love calling it) then, the brain tissue simply LIQIUIFIES in an effort to make more room. Disgusting right?! When your brain liquefies, you get signs and symptoms associated with damage in that place – if you hit a small area and just nerves and radiations of nerves, your body can often recover loss of sensation or muscular weakness on one side of your body. When you hit a nerve nucleus, like the facial nerve cell body nuclei, you probably wont recover those functions because the cells themselves are dead.

Apparently I still need to learn more about strokes, especially the ones that can kill you. What I do know, is high blood pressure, diabetes and smoking are huge risk factors for stroke, and those are all related to will power. So, you do have a choice, like I do, about how to live on a day to day basis. I am choosing to decrease my daily alcohol content to improve my studying. What will your choice be?

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