Fertility is the New Holy Grail

Resolve to know more about the underling factors affecting conception and alternative family possibilities. * This article was originally written for the February 2015 Digital Issue of Essential Living Maine*

I had two stepmothers who were infertile for various reasons, and have an adopted baby brother. Several of my close friends and family member have used IVF to conceive, and I have my eggs cryopreserved. A few of my good friends have fostered and adopted, and others have intentionally chosen childfree lives. As lesbian and gay marriage has normalized, and divorce rates have climbed, more and more alternative families are being created using sperm banks, surrogates, egg donors, known sperm donors and more. The quest for fertility is all around us, and has been for the past 30 years in ever-increasing numbers.

The Internet has an enormous amount of information available on this topic, as the World Wide Web offers an enormous cross cultural support network for women trying to conceive (#TTC.) Infertility is usually a silent disease without any visible disability associated; however, it draws deeply on the mind/body and soul in underground ways that cannot be explained to those who do not have to undergo its trails and tribulations. Thus, the web is a great way to connect, share information, and do research while maintaining public anonymity.

220px-Sangreal-1Integrative Medicine is key to enhancing fertility. Integrative Medicine combines the best of modern medicine (reproductive technology) with time-honored complementary and alternative medicines (botanical therapies, clinical nutrition, homeopathy, acupuncture, and stress management support.) The quest to get pregnant (and stay pregnant!) has been a calling of doctors and midwives since the beginning of time and across all cultures.

After ten years of fertility specialization, here are my Top Ten Integrative Medicine Fertility Fundamentals to know about when mapping your journey:

  1. First, while on oral contraceptive pills, rings, or IUD’s and for at least 6 months coming off them, it is important to supplement with a good quality multivitamin that contains at least 10-20mg of all of the B vitamins, magnesium, vitamin C, and 800mg folic acid. These are depleted by synthetic estrogens, and a deficiency can cause long term fertility issues down the road.
  1. If you have a family hx of miscarriage, have had a miscarriage yourself, or have any anemia or high homocysteine on lab work, you may want to test for a genetic defect called MTHFR that leads to a folic acid absorption issue. http://www.apothecarybydesign.com/blog/archives/332
  1. DHEA is a fat-soluble antioxidant and hormone precursor produced by the adrenal glands. DHEA is also a key player in egg health, showing improved embryo quality and higher live birth rates than controls. Studies have used 75 mg of DHEA daily. 1 DHEA supplementation also evidenced higher rates of spontaneous pregnancies in long-term poor responders to IVF in another study using 25 mg three times per day. 2 DHEA supplementation slows the aging process by preventing lipid oxidation while improving energy and metabolism.
  1. CoQ10 is imperative to egg health. Egg division from 46 to 23 chromosomes requires effective mitochondrial function. 3. It has been suggested that mitochondrial DNA defects that effect metabolic capacity may be a cause of failure in egg maturation, fertilization, or early embryonic development. 4. Aged eggs have decreased mitochondrial energy which can result in deficient energy to divide properly resulting in Downs’s syndrome and other genetic anomalies. All women over 30 who are still considering pregnancy should be on 100mg of ubiquinol daily to maintain efficient mitochondrial activity.
  1. Test your hormones early, and keep testing every few years for an objective measurement of fertility reserves. Follicle Stimulating Hormone (FSH) levels must be tested on day 3 of the menstrual cycle with Anti Mullerian Levels (AMH) levels before beginning fertility protocols. FSH reflects the relationship between the ovaries and pituitary and higher levels indicate perimenopause and poor ovarian function. Therefore, levels of FSH under 10 are best. AMH is also called the “egg timer” as it gives an accurate level of the follicular reserves of the ovaries. AMH levels do not fluctuate throughout a cycle and can be tested at any time. Serum AMH levels decline throughout ones reproductive life cycle, and are undetectable after menopause; therefore, higher levels are more desirable.
  1. Don’t wait too long to consider IVF. If you have been #TTC for more than 9 months and have not become pregnant with regular, timed inseminations, IUI’s or intercourse, make appointments with a fertility clinic and an Integrative fertility specialist. Having a Plan B will decrease stress, and it takes time to consider the financial and medical burdens associated with reproductive technology. However, it is worth it to have that baby in your arms! If IVF is needed, committing to the process earlier in your fertility journey can increase your chances for that #BFP (Big Fat Positive) on your first attempt.
  1. Don’t forget the men! At least 30% of infertility is male factor. Too often one half of the couple is doing everything possible (yoga, clean eating, no caffeine, no alcohol, meditation, support group, acupuncture, etc) while the other half is the root cause of the issue. Getting a sperm analysis is one of the first steps in a fertility evaluation, and can bypass months of angst from non-conception.
  1. Sperm need fertility enhancing supplements too! Omega 3 fats, 15 mg zinc, and stress busting herbs like Maca or Ashwaganda will improve sperm health, tonify libido and boost fertility.
  1. Have your thyroid hormones including TSH, Free T3 and Free T4 and your progesterone levels tested. Low thyroid function leads to low progesterone, which leads to frequent miscarriage in a classic vicious cycle. Some Endocrinologists and Family Docs may have conservative opinions on these levels and may use outdated reference ranges or be unwilling to test for Free T3. Consulting an Integrative Medicine Doc, Naturopathic Doctor or anti-aging Hormone Doctor may give you more information about optimizing your hormone levels rather than operating at a subclinical deficiency.
  1. Consider alternatives to the traditional nuclear family. There are many beautiful babies who want safe, stable, loving homes and need fostering and adoption. I know three amazing families of beautiful fostered babies! There are also women able and willing to carry babies to create families that are not their own. While a biological birth is what we are taught to dream for, this is not the answer for some. Infertility is tragic and real for people who have always assumed they would be able to birth when they are ready. Allow your self to grieve as a couple, but do not close the door on other options even if they seem inconceivable at first.

On another note, childfree living also has many blessings. Our culture is slowly shifting away from the definition of having a (nuclear) family as the ultimate success. Childfree living allows for a more relaxed and abundant lifestyle with more freedom, ability to travel, and heightened romance for a couple. We are an overpopulated planet, and I know from my life, having an auntie that is invested and involved in my life is incredibly valuable. Here are many ways to be a part of a family, and each version needs to be recognized as equally valuable and important!

I could keep typing another ten set of treatments supports, and probably another ten after that,  I am so passionate about fertility! However, as I said earlier the Internet is a rich resource. Some other articles I have written on the topic include:

I wish each of you success on your Holy Grail of Fertility. May your journey connect you to your own Divine nature as you experience one of the great, uncontrollable mysteries of life: Conception!

References

  1. Addition of Dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod.  2010; 25(10): 2496-500Accessed September 13 2013
  1. Leonidas mamas, Eudoxia Mamas. Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Current Opinion in Obstetrics and Gynecology 2009, 21:306-308.
  1. David Meldrum, MD. Aging gonads, glands, and gametes: immutable or partially reversible changes? Fertility and Sterility 2013; 99:1-4.
  1. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertility and Sterility 2010; 93:272-5.

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http://www.agemanagementcenter.com/contact-amc/  or call 207-774-1356

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Using Herbal Medicine in Pregnancy

pregnancy-tonic-tea-220x231There are always questions about which herbs are safe to use in pregnancy. There is considerable historical and clinical information on the use botanical medicine for enhancing fertility, treating common conditions of pregnancy, and supporting postpartum care and lactation. The modern push for evidence-based studies to confirm safety of use is hindered by the ethical issue of conducting clinical trials during pregnancy. Therefore, there are very few if any double blind placebo controlled studies to reference for this population. For this reason, most online and allopathic resources will list herbs as “not safe in pregnancy” even if they have been safely used for centuries as part of maternal medicine. Furthermore, the World Health Organization label requirements for botanical medicines includes information on the use during pregnancy and lactation. As there is insufficient evidence-based studies on botanicals in pregnancy, almost all products will say Not Safe in Pregnancy or Lactation. This is good in some ways, because it protects the fetus from harmful herbal constituents accidentally taken by an unsuspecting parent. On the other hand, it limits many people from accessing safe and effective supportive herbal therapies during this unique time of life.

As a general rule of thumb, almost all herbs are best avoided during the first 12 weeks of pregnancy unless specifically prescribed by an expert in this field. Ginger is one exception to this, as it has significant clinical evidence to reduce nausea of pregnancy. Still, even ginger can be too stimulating and is best taken in moderation. *Dosage for hyperemesis gravidum could be 5-10 drops of a ginger glycerite tincture as needed, up to 70 drops daily. Ginger tea or  chrystallized ginger can be used 2-4 times a day, and ginger candies up to 10 daily. Roobios is another herb that is a safe tea in early pregnancy. This is a traditional pregnancy medicine in Africa, and a very common tea base. Nettles are also very gentle and provide a mineral-rich tonic for the newly pregnant mom. Nettle is a lovely tea base to use throughout pregnancy and lactation for hydration and nourishment. As every person’s body is different, it is sometimes best to stick with what your body knew pre-pregnancy rather than trying new things in these sensitive weeks to avoid unexpected allergic reactions or other physical repercussions.

There are some herbs which must be completely avoided throughout pregnancy as these are known to be harmful in some way. For a complete list see:  http://thewrightdoctor.com/womens-health-2/herbs-not-safe-in-pregnancy/

Herbs with strong alkaloids (identified by a bitter taste) are to be avoided. These often have a strong action on the body, whether digestive or cardiac. There are many gentle herbs and nutritional supports which are safer digestive tonics for pregnancy. Laxative herbs exert their effects through muscular contractions and can stimulate uterine contractions as well. Most herbs with strong hormonal activity are to be avoided completely , as are all anti-parasitic formulas. Certain herbs that are to be avoided in pregnancy can be prescribed by experts in this field in the last few weeks of pregnancy to prepare the uterus for labour.  These are only to be used under the guidance of an experienced midwife or prescribing professional with obstetric training in botanical therapies.

There are many herbs which help pregnant women connect to their body and the environment in a grounding, tonifying way that are safe and effective. Some women will make their own creations from local plants, and others will buy them. When purchasing plant remedies, it is important to buy from reliable brands. Gaia, Apollo herbs, Herb Pharm, Vitanica, Wise Woman and Avena Botanicals are all ethical and responsible manufacturers of high quality herbals. If you are concerned about whether or not a product is safe for you, simply do not use it! Or, find a local Naturopathic Dr, Midwife, or Herbalist to guide you in your pregnancy care.

These are some herbs which are safe to take. * Alfalfa is very high in chlorophyll and rich in minerals and vitamins. This is a great greens powder in smoothies. Burdock can be used in small doses of 20 drops 1-2 times a day after the first trimester. Burdock supports women with blood sugar difficulties or constipation later in a pregnancy. Dandelion greens are a great tonic for women pregnant in the spring. They are robust in vitamins and strengthen the urinary system. Dandelion root can also be used in small amounts like burdock, for sour stomach, nausea and itchy skin. Oatstraw is a soothing tea or tincture which calms an overstimulated nervous system. This is a must have for pregnant moms with other small children! Up to four cups of Oatstraw tea daily is safe or use in tincture form 40-60 drops in water 2-3 times a day.

Rose hips are safe throughout pregnancy. These have abundant vitamin C to support collagen production in skin and help maintain vascular wall integrity.  They have a sour zip, and make a yummy tea with nettle and honey. Saint Johnswort herb is a safe and gentle mood support during pregnancy as well as a safe option to treat herpes outbreaks both topically and internally. It should not be used with other medications, but is a reliable ally for women during this time of life. Red raspberry leaf is very well known as a late pregnancy tonic. This silvery-green leaf strengthens the uterine muscle without stimulating contractions, preparing the body for the adventure of labour. It is rich in iron to support the increased blood volume in later pregnancy. It is best drank as a tea 1-3 cups per day for the third trimester. Finally, Valerian is a safe sleep support. It is best to use the smallest dose needed for therapeutic value, so start with 1 cup tea before bed or 10-30 drops of tincture and increase as needed.

Pregnancy is a time of life when so much is unknown, and so much can go wrong – there is so much responsibility for both parents and care providers. For this reason much of modern medicine has erred strongly on the side of caution when it comes to using herbal medicines in pregnancy. This caution is compounded by the high cost that many IVF assisted pregnancies carry. Every move becomes highly medicalized, and simple acts like a cup of herbal tea are forgotten as effective therapeutics. The bottom line when it comes to using herbs in pregnancy is: if it makes you nervous, dont do it. You cannot rely on the internet, on your OB,  or on labels to tell you what is safe to take during this time of life. However, there are some very reliable books on using herbs in pregnancy, and many Herbalists, Naturopathic Doctors and Midwives have expertise in this area. Enjoy!

http://apps.who.int/medicinedocs/en/d/Jh2945e/9.5.html

http://www.ahpa.org/default.aspx?tabid=70

*ABC Clinical Guide to Herbs. M. Blumenthal p. 174

*The Natural Pregnancy Book. Aviva Jill Romm

*Herbal Childbearing Year. Susun Weed p. 19, 51

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#TTC – Safe Treatments for Fertility & First Trimester Anxiety

The work of becoming/being pregnant marks a time in a woman’s life when the game changes. Alcohol is no longer an option for stress management. Most herbs and even common teas are viewed with suspicion, and many medications are frowned on. Many of our crutches for managing the stresses of daily life are taken away, and the stress of in/fertility is added. However, there are natural treatments available for this time period to reduce stress, ease anxiety, and support a healthy first trimester.

Flower Essences are very safe for all expecting and #TTC moms, and are especially useful for women using multiple fertility and metabolic medications as they have no interactions or side effects! Flower remedies are literally essences of the particular flower in a brandy solution. Bach flower essences are the most commercially available. FES (Flower Essence Society,) Alaskan Essences, Perelandra and more are other well respected flower essence brands. Bach has 38 different flower remedies available; however the following are especially pertinent for fertility and first trimester. Dosage is 3-5 drops in water 2-4 times daily or as needed. The very small amount of alcohol in these medications will not cause any fetal problems as it is so minute a dose.

Aspen: For apprehension and vague fears

Gorse: Brightens perspective and increases optimism.

Holly: For envy or jealousy of others

Larch: Gets one out of the success/failure paradigm and increases self-confidence

Wild Rose: Restores interest and joy when feeling apathetic or resigned.

White Chestnut: Restores a peaceful mind when caught in repetitive thoughts

Botanical Medicine: Some herbs are appropriate for this time period, however most herbs are best set aside until the pregnancy is well established or beyond breastfeeding. One herb that is a #TTC and first trimester best friend is viburnum prunifolium otherwise known as black haw. This is different from viburnum opulus aka cramp bark – do not mix the two! Black haw quiets an “irritable” uterus, and prevents miscarriage. It is very safe and quite effective. I recommend 1/4 to 1/2 tsp daily for the first trimester as needed. For questions and concerns, refer to your local Naturopathic Doctor who can take your full history and prescribe according to your individual health care needs. Oatstraw or avena sativa is also a wonderful tonic that is nourishing to the body and calming to the mind. This herb is best taken as a tea. It is gluten free, hydrating with rich minerals (therefore great for morning sickness) and soothing to frazzled nerves. Valerian is perfect for nighttime anxiety. It is safe in pregnancy, breastfeeding, and for pediatrics. This is Mother Nature’s truly sedative herb. Used in doses of 5-30 drops before bed, this can help quiet the mind and improve the duration and quality of sleep. I like it as an alcohol free (glycerite) tincture as the taste is slightly sweeter than the alcohol based formula. Capsules are also an option although I prefer the smaller dosing options of the liquid form. (Valerian is very well researched, please contact me for a formal monograph if desired.)

imagesFinally, lavender essential oil has a time honored place in the treatment of anxiety.  For those whom lavender has a calming effect you can use lavender products liberally that have the real essential oil in them – avoid synthetic fragrance analogues. There are now lavender essential oil capsules that are quite effective for treating occasional or situational anxiety. These act quickly and safely to diminish feelings of panic, irritability and stress. Typically essential oils should not be used internally during pregnancy, so these lavender caps are best used only until the day of ovulation. There is a lavender glycerite tincture also available which can be used sparingly while pregnant in doses of 1-2 drops for anxiety and panic as needed. There is some (internet) controversy surrounding the use of lavender in pregnancy; however, it is not listed in any of the classic literature as a herb to avoid in first trimester.  My opinion is that if this botanical medicine is the one thing that works to soothe your fears, use it in moderation. If it increases your anxiety due to the multitudes of internet opinions, avoid it! Here is a link to a well researched blog post on the safety of lavender essential oil in pregnancy: http://roberttisserand.com/2011/07/lavender-oil-and-pregnancy/

Acupuncture and Registered Massage Therapy are also fabulous safe care therapies for anxiety and stress while #TTC. Acupuncture has a proven track record of efficacy when it comes to enhancing not only assisted reproduction but also all conception. Studies have shown that weekly acupuncture greatly reduces the rate of miscarriage during first trimester, especially for women with a previous miscarriage. This is in part due to its ability to support the expectant mom through the first 12 weeks. The therapeutic touch offered by massage therapy also has the ability to soothe anxiety, ease depression, and support the physical changes of pregnancy. The resulting relaxation offers an anxious expecting mom a few moments to quiet the mind, which can have great positive effects overall. It is important to see an acupuncturist or massage therapist trained in pregnancy massage as there are specific techniques and positions used for this treatment.

All in all, this is such a time of mystery, of waiting, and of trust that it can be overwhelming to have to “go with the flow.” Every couple experiences some level of anxiety, and some have a very hard time as #BFN’s happen again and again.  Flower essences, black haw, oatstraw and lavender glycerite are natural remedies that any couple can use to support their own mental and emotional wellness on the road to becoming a family. There are many more herbs, vitamins, and therapies available for #TTC and expectant moms that are based on the individualized medicine offered by a licensed Naturopathic Doctor.

Links and Resources:

http://www.gowonderworks.com/flower_essences

http://www.bachflower.com

http://www.fesflowers.com

http://www.biomedcentral.com/1472-6882/12/20

http://www.fertilityfactor.com/infertility_acupuncture.html

http://americanpregnancy.org/pregnancyhealth/prenatalmassage.html

 

 

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