A Pandemic Wasn’t The Plan: Part 3 – Hormones 05/11/2020

Well, I bled for 16/30 days in April plus 5 in May. This is not my normal. This is pandemic menses. I don’t remember the relationships between cortisol, ovarian function and the reproductive cycle and frankly I haven’t had the energy to look it up again. I am also 46, so my ovarian reserves are low and having anovulatory/ short cycles could be the new normal until I get fully into bioidentical hormone replacement land. Still: Why such extended Abnormal Uterine Bleeding (AUB) ? And why this extended pain, expense and moodiness when I am already working long hours, alternating day and night shifts, and having to accept the global panic of COVID?

I have not changed much of my regular hormone regime. I have been taking bioidentical progesterone the second half of my cycle for the past 10ish years. Ovaries start decreasing progesterone production around 35yo often causing worsening PMS, cramps, and shorter lighter cycles. Taking progesterone lengthens my cycle from 21 to 26ish days and really helps with cyclic breast pain, bloating, cravings, PMDD and cramps. I had been on vacation when all this started and had not been taking it consistently 🙁

I also take testosterone as a subQ injection intermittently. It is prescribed as a weekly shot, but I tend to take it only every 2-3 weeks, mostly because I forget. Sometimes I forget to take it for months at a time. Cis female ovaries and adrenals produce small amounts of testosterone throughout the lifetime, and testosterone is the dominant cisfemale hormone of menopause! Endogenous production tends to decrease around age 40 as an average.

When I was working at Age Management Center, I tested dozens of women’s testosterone levels between ages 25-75 and it was extremely common to have very low levels: more common than normal levels! Optimization of this all-gender hormone brings a sense of vitality, physical and mental strength, increased muscle mass, heightened endurance, and improved orgasm strength (or orgasms, maybe for the first time!) It helps me have the energy to get to the gym and enjoy workouts. I also had an improvement in libido and sexual satisfaction. I have been taking this rx more frequently these days as internal medicine is *exhausting* so low T is not at the root of my hormonal shifts.

That leaves estrogen as the possible culprit, and this could certainly be the case.There are 3 different estrogens in the body that can be measured. Estradiol is the major circulating hormone that has all the beneficial effects – elasticizing bone, brain, blood vessels, and skin. Estrone is a metabolite of both testosterone and estradiol through aromatization and is theorized to have more inflammatory and proliferative effects. The ideal Estradiol: Estrone ratio is 2:1in the body. Estriol is the weakest estrogen and is localized to the uterus and vagina. This enhances vaginal lubrication and tissue health. It is also what is typically used for vaginal replacement in menopause or transmasculine health because it has less systemic effects. I am due to go get my hormone levels tested to see of I have had a big shift in estrogen levels. Lab work is ideal when done between days 19-21 of a cycle to catch all 3 hormone levels. I have not had any side effects of low estrogen yet, but as a 46yo, the decrease is coming.

I will likely transition to bioidentical hormone replacement when my ovaries retire fully. Humans used to go into menopause around 50-55 then die around 65. I do not think we were made to live an extra 40-50 years (90 yo) without any gonadal hormones. And as someone who will be in high productivity for many years head working in medicine, I will need these juicy, foundational, resilient, life giving hormones! Plus, I love the feeling of being strong physically, mentally, sexually and emotionally!

What about Breast Cancer you ask? Well, fortunately I do not have the gene that puts me at higher risk. I also eat lots of foods full of plant nutrients, antioxidants, fibers, and phytochemicals and good quality meats and fats. I exercise occasionally, especially out in nature where I can fill my lungs with fresh oxygen. I have a lot of stress in my life, but I do my best to counteract that with affection, loving kindness towards myself, sleep, mindfullness meditation, therapy, strong friendships and sunshine/water/flowers. Estradiol does increase proliferation of breast tissue; bioidentical progesterone counteracts that maintaining a balance of growth and suppression. Testosterone itself is also apoptotic meaning it is anti-cancer/ pro cellular health in nature. For me, in this body, having a well of hormones to draw from as I continue to function in the world is a source of inner vitality that I can give myself, even when my ovaries stop being able to produce it themselves. And, I will probably stop full bHRT after around 15 years, which is what evidence has shown is the time when long term hormone replacement therapy in ciswomen stops being as effective and starts to drift towards harmful. I may even just continue testosterone in those years which has less negative evidence as well as less links to breast pathology.

I have effectively convinced myself this was probably an estradiol dip in ovarian production resulting in a very short cycle partially due to low progesterone followed by an ovulatory but still low estrogen short cycle. Fingers crossed that this is not my new normal. I have also re-upped my commitment to taking my daily thyroid medication as well as adrenal herb supports, because the hormone systems all work in tandem and when one part is dysfunctional, others need to work extra hard. But the adrenal and thyroid systems are a whole other conversation for another day. And maybe I will read up more on the links between stress and hormones between now and then.

http://resources.ama.uk.com.s3-eu-west-1.amazonaws.com/glowm_www/graphics/figures/v5/0060/014f.jpg

Meanwhile, This Gal needs to get ready for her night shift in the COVID ICU. Stress. Yup. Exhausting emotionally and physically. Yup. My ovaries can probably read the cortisol and adrenaline levels in my blood and there may be another month of AUB ahead as my body instinctively tries to preserve its resources for essential functioning only in these pandemic times. At least I know what to do for it! I also did book an appointment with a new gynecologist to have an expert on board in case I need something like imaging or a more extensive workup. A Doctor cant always heal herself!


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Fertility is the New Holy Grail

Resolve to know more about the underling factors affecting conception and alternative family possibilities. * This article was originally written for the February 2015 Digital Issue of Essential Living Maine*

I had two stepmothers who were infertile for various reasons, and have an adopted baby brother. Several of my close friends and family member have used IVF to conceive, and I have my eggs cryopreserved. A few of my good friends have fostered and adopted, and others have intentionally chosen childfree lives. As lesbian and gay marriage has normalized, and divorce rates have climbed, more and more alternative families are being created using sperm banks, surrogates, egg donors, known sperm donors and more. The quest for fertility is all around us, and has been for the past 30 years in ever-increasing numbers.

The Internet has an enormous amount of information available on this topic, as the World Wide Web offers an enormous cross cultural support network for women trying to conceive (#TTC.) Infertility is usually a silent disease without any visible disability associated; however, it draws deeply on the mind/body and soul in underground ways that cannot be explained to those who do not have to undergo its trails and tribulations. Thus, the web is a great way to connect, share information, and do research while maintaining public anonymity.

220px-Sangreal-1Integrative Medicine is key to enhancing fertility. Integrative Medicine combines the best of modern medicine (reproductive technology) with time-honored complementary and alternative medicines (botanical therapies, clinical nutrition, homeopathy, acupuncture, and stress management support.) The quest to get pregnant (and stay pregnant!) has been a calling of doctors and midwives since the beginning of time and across all cultures.

After ten years of fertility specialization, here are my Top Ten Integrative Medicine Fertility Fundamentals to know about when mapping your journey:

  1. First, while on oral contraceptive pills, rings, or IUD’s and for at least 6 months coming off them, it is important to supplement with a good quality multivitamin that contains at least 10-20mg of all of the B vitamins, magnesium, vitamin C, and 800mg folic acid. These are depleted by synthetic estrogens, and a deficiency can cause long term fertility issues down the road.
  1. If you have a family hx of miscarriage, have had a miscarriage yourself, or have any anemia or high homocysteine on lab work, you may want to test for a genetic defect called MTHFR that leads to a folic acid absorption issue. http://www.apothecarybydesign.com/blog/archives/332
  1. DHEA is a fat-soluble antioxidant and hormone precursor produced by the adrenal glands. DHEA is also a key player in egg health, showing improved embryo quality and higher live birth rates than controls. Studies have used 75 mg of DHEA daily. 1 DHEA supplementation also evidenced higher rates of spontaneous pregnancies in long-term poor responders to IVF in another study using 25 mg three times per day. 2 DHEA supplementation slows the aging process by preventing lipid oxidation while improving energy and metabolism.
  1. CoQ10 is imperative to egg health. Egg division from 46 to 23 chromosomes requires effective mitochondrial function. 3. It has been suggested that mitochondrial DNA defects that effect metabolic capacity may be a cause of failure in egg maturation, fertilization, or early embryonic development. 4. Aged eggs have decreased mitochondrial energy which can result in deficient energy to divide properly resulting in Downs’s syndrome and other genetic anomalies. All women over 30 who are still considering pregnancy should be on 100mg of ubiquinol daily to maintain efficient mitochondrial activity.
  1. Test your hormones early, and keep testing every few years for an objective measurement of fertility reserves. Follicle Stimulating Hormone (FSH) levels must be tested on day 3 of the menstrual cycle with Anti Mullerian Levels (AMH) levels before beginning fertility protocols. FSH reflects the relationship between the ovaries and pituitary and higher levels indicate perimenopause and poor ovarian function. Therefore, levels of FSH under 10 are best. AMH is also called the “egg timer” as it gives an accurate level of the follicular reserves of the ovaries. AMH levels do not fluctuate throughout a cycle and can be tested at any time. Serum AMH levels decline throughout ones reproductive life cycle, and are undetectable after menopause; therefore, higher levels are more desirable.
  1. Don’t wait too long to consider IVF. If you have been #TTC for more than 9 months and have not become pregnant with regular, timed inseminations, IUI’s or intercourse, make appointments with a fertility clinic and an Integrative fertility specialist. Having a Plan B will decrease stress, and it takes time to consider the financial and medical burdens associated with reproductive technology. However, it is worth it to have that baby in your arms! If IVF is needed, committing to the process earlier in your fertility journey can increase your chances for that #BFP (Big Fat Positive) on your first attempt.
  1. Don’t forget the men! At least 30% of infertility is male factor. Too often one half of the couple is doing everything possible (yoga, clean eating, no caffeine, no alcohol, meditation, support group, acupuncture, etc) while the other half is the root cause of the issue. Getting a sperm analysis is one of the first steps in a fertility evaluation, and can bypass months of angst from non-conception.
  1. Sperm need fertility enhancing supplements too! Omega 3 fats, 15 mg zinc, and stress busting herbs like Maca or Ashwaganda will improve sperm health, tonify libido and boost fertility.
  1. Have your thyroid hormones including TSH, Free T3 and Free T4 and your progesterone levels tested. Low thyroid function leads to low progesterone, which leads to frequent miscarriage in a classic vicious cycle. Some Endocrinologists and Family Docs may have conservative opinions on these levels and may use outdated reference ranges or be unwilling to test for Free T3. Consulting an Integrative Medicine Doc, Naturopathic Doctor or anti-aging Hormone Doctor may give you more information about optimizing your hormone levels rather than operating at a subclinical deficiency.
  1. Consider alternatives to the traditional nuclear family. There are many beautiful babies who want safe, stable, loving homes and need fostering and adoption. I know three amazing families of beautiful fostered babies! There are also women able and willing to carry babies to create families that are not their own. While a biological birth is what we are taught to dream for, this is not the answer for some. Infertility is tragic and real for people who have always assumed they would be able to birth when they are ready. Allow your self to grieve as a couple, but do not close the door on other options even if they seem inconceivable at first.

On another note, childfree living also has many blessings. Our culture is slowly shifting away from the definition of having a (nuclear) family as the ultimate success. Childfree living allows for a more relaxed and abundant lifestyle with more freedom, ability to travel, and heightened romance for a couple. We are an overpopulated planet, and I know from my life, having an auntie that is invested and involved in my life is incredibly valuable. Here are many ways to be a part of a family, and each version needs to be recognized as equally valuable and important!

I could keep typing another ten set of treatments supports, and probably another ten after that,  I am so passionate about fertility! However, as I said earlier the Internet is a rich resource. Some other articles I have written on the topic include:

I wish each of you success on your Holy Grail of Fertility. May your journey connect you to your own Divine nature as you experience one of the great, uncontrollable mysteries of life: Conception!

References

  1. Addition of Dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod.  2010; 25(10): 2496-500Accessed September 13 2013
  1. Leonidas mamas, Eudoxia Mamas. Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. Current Opinion in Obstetrics and Gynecology 2009, 21:306-308.
  1. David Meldrum, MD. Aging gonads, glands, and gametes: immutable or partially reversible changes? Fertility and Sterility 2013; 99:1-4.
  1. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertility and Sterility 2010; 93:272-5.

To book an appointment:

http://www.agemanagementcenter.com/contact-amc/  or call 207-774-1356

Clinical Practice:

www.agemanagementcenter.com

www.facebook.com/AgeManagementCenter

For more information about Infertility see:

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Reflections from the Philadelphia Trans Health Conference 2013

What a phenomenal catalyst for change. June 13-15 was the 12th annual Trans Health Conference in Philly. It was a massive collection of workshops on many different aspects of Transgender, Transsexual and differently gendered health and healing including medical, legal, spiritual, practical aspects, self-empowerment and so much more. I was honored to be a presenter this year on Naturopathic Medicine and Trans Health. It was my first time attending the conference, and I am so impressed by the caliber of the event. I primarily attended medical style workshops including presentations on the most recent research being done with the trans community.

My talk was a great learning process for me. Not only from the questions asked by the diverse and well informed crowd, but also as a reflection of self. I am very comfortable in the trans community, consider myself an ally, and am aware of the multidimensional and sometimes fragile nature of trans identities. And yet, twice during my presentation I wrongly identified someone as a woman and a man when calling on people for questions. Under pressure, my highly educated nervous system switched back to my reptilian brain of the binary He-She world – and this with all the *knowing* that I have of the great diversity of gender expression. I was disappointed in myself.  It is a lesson that in working with this community, it is especially important to be conscious of language. The old ways of thinking are simply not progressive enough to enter the dialogue. For example, when referencing  people, we as a society need to step outside of classifying people by sex (and race.) Instead of saying “the woman in the yellow shirt”, say “the person in the yellow shirt is ….” The majority of the time our binary classification may be right, but there is a significant proportion of times when our 2D classifiers are actually incorrect, and those can be very painful moments for the individual inhabiting the misread gender identity.

I also talked about adrenal health, and was pleased to learn of new research that evidences salivary cortisol levels are indeed raised higher in the transitioning trans population than in controls. Meaning – stress is huge. Everyone working with trans people of all identifications will need to do stress management and adrenal support. Adrenals are also a source of endogenous hormones including DHEA, which could be a resource for transmasculine and transfeminine people not taking hormones as it has the potential to shift to both testosterone and estrogen internally.  There were many questions about the use of botanicals that have been evidenced to have steroid-like action. This is an area I need much more clinical experience in.

I was heartened to meet 3 other Naturopathic Doctors and two herbalists working in this field at the conference, all of who gave presentations as well.  They reminded me of some of the important preventative medicine aspects of working with people on hormone therapies like hypertension, osteoporosis, calcium quality, high cholesterol and so much more. There were also acupuncturists, and ayruvedic practitioners offering other traditional perspectives. Next year I hope to cultivate a workshop where we all meet to share information! I know I was left with more questions than answers.

I learned important information about our trans youth, and ways to support them better from both a practical level in schools, around mental health, and medically. Dori Midnight, a Massachusettes healer and fairy witch did workshops in mental health, herbalism and ancestral trans magics. I also got to share a room with her, which was a delightful meeting of the minds with gluten-free snacks. There were many sessions on identity development and closed meetings for specific gendered health care needs that looked inspiring and transformational. There were many fantastic workshops I did not get a chance to attend, including a 2 day medical training stream which I will certainly do next year.

Overall, the experience was one that provoked intense introspection and profound leaps of knowledge. It was an event that is crucially important to modern medicine, to understand not only the vernacular but also the urgency of the need for competent health care providers AND self care within the transgender, transsexual and gender non-conforming communities.

A few links and resources from the conference:

http://www.trans-health.org/

http://www.dorilandia.com/html/home.html

http://thirdroot.org/

http://www.rainbowhealthontario.ca/admin/contentEngine/contentDocuments/Gender_Independent_Children_final.pdf

www.riverstoneconsult.com

www.gendercreativekids.ca

www.fenwayhealth.org/transhealth

 

 

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Improving Libido with Naturopathic Medicine

Sex, sex drive and inherent libido are all very complex subjects in modern culture, affected by our extremely long TO DO lists tagged onto the ends of busy days. Here is an article I wrote for QueeriesMag.com February 2013 on Naturopathic Medicine to increase sex drive.Let me know what you think!

http://queeriesmag.com/index.php/2013/02/14/on-the-kitchen-table/

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A Note from Behind the Curtain

So many patients are looking for answers. As a doctor I know that the best answers are in each individual. Usually, we do not want to know the real answer. We want a pill, or a cream, or a smoothie containing the essential nutrients that will add up to the ultimate results. Dont get me wrong – products will help. Testing can uncover imbalances and deficiencies to be corrected and appropriate formulations to improve symptomology. However… until you are actually ready to change something – that thing- – which needs changing in your personal landscape, it is unlikely that you will find your own true answer to health. I will use myself as an example.

After I graduated from Naturopathic Medical School in 2000, I opened a clinic in downtown Toronto with some of my classmates. Over the next 12 years I developed my professional identity, grew my patient base, and pursued my personal passion of fertility medicine. I had a wonderful partner, a beautiful home and fantastic friends. I was never fully content, despite my abundance. I doubted my career and profession, and was constantly seeking something outside of myself to fill the inherent void. No amount of adrenal supplements, detox regimes or magnesium quieted the inner voice. This was not an organic condition, it was a calling that took me many years to acknowledge.

Eventually, I moved to Portland Maine in March 2011. I sold my clinic, left my clinic faculty position, and my sweetheart and I parted ways. Here, life is different. I smell the ocean every day. I do yoga (occasionally.) I walk the dog. I drink green tea. I am redefining myself as a Naturopathic Doctor and am inspired by the new turns my professional identity is taking. I am becoming a better doctor – the best version of myself. It has been a massively stressful process to redefine my life in my late 30’s. However – the gray hairs are worth the evolution. I am happy in a way I have never been. And it is not because my physical, emotional, or mental health has changed drastically. It is because I have found my own answer.

Not everyone’s answer will involve so many miles and such upheaval. The answer to your own health and wellness questions may simple or complex. Part of my job as a Naturopathic Doctor is to look beyond pills and dietary restrictions to see your truth behind your curtain, and support you in finding your own evolutions. If I can do it, I am sure to believe in you.

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